KAIST Research Team Develops Platform for Enzyme Reaction
KAIST Research Team Develops Platform for Enzyme Reaction Joint Research Conducted by Professors Chan Beum Park and Ki Jun Jeong Medical Supplies with High Added Value Expected with Low-Priced Dyes
Research teams led by Professor Chan Beum Park (Department of Materials Science and Engineering) and Professor Ki Jun Jeong (Department of Chemical and Biomolecular Engineering) developed a new reaction platform that uses light to induce enzyme reaction of drugs.
▲ Diagram of electrons being transferred from light to cytochrome P450 enzyme through eosin Y (EY)
With this technology, it is expected to become possible to use low-priced dyes to produce medical supplies with high added value, including medicine for cardiovascular disorders and gastric ulcer treatments, such as omeprazole.
Instead of expensive NADPH, the research teams used eosin Y (EY), a cheaper photosensitizer that reacts to light, to develop the procell photo-biocatalyst, which is based on the colon bacillus.
Under this new principle, metabolic material is produced by exposing EY to light and thereby stimulating the reaction of cytochrome P450, the enzyme that brings about an important oxidation reaction in the course of the metabolism of drugs or hormones.
Cytochrome P450 is known as a critical element in the process of drug development because it is responsible for at least 75 percent of the metabolism of drugs administered to humans.
NADPH, a coenzyme within cells, is necessary to activate cytochrome P450. Due to the high price of NADPH, however, cytochrome P450 had been used only at laboratories and has not played a sufficient role in the industrial context.
“Our research made it easier to utilize cytochrome P450, whose industrial use had been highly limited,” Professor Park said. “Our technology will be of great help in utilizing the enzyme to produce medical supplies with high added value.”
The research results were published on January 12, 2015, as the back cover article in Angewandte Chemie, an international chemistry journal.
Advised by Professors Park and Jeong (corresponding author), doctoral student Jong Hyun Park and Dr. Sang Ha Lee participated in this research as lead authors. The research received support from the Mid-Career Researcher Program and the Global Frontier Program sponsored by the National Research Foundation of Korea, as well as from the KAIST High Risk High Return Project.
▲ Professors Chan Beum Park and Ki Jun Jeong, Mr. Jong Hyun Park, and Dr. Sang Ha Lee(from left) (Photo courtesy of KAIST)
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