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Designer proteins with chemical modifications

작성자 : KAIST 등록일 : 2017-09-22 조회수 : 2836 메일 : jsoh33@kaist.ac.kr
Author : Hee Sung Park Publication Date : 2016
Summary:
We developed a new strategy for installating authentic posttranslational modifications into recombinant proteins. We first create a phosphoserine-containing protein using the established O-phosphoserine orthogonal translational system. The phosphoserine residue is then dephosphorylated to dehydroalanine. Finally, Zn-Cu promoted conjugate addition to dehydroalanine of alkyl iodides enables chemo-selective carbon-carbon bond formation. Using well-tailored alkyl iodide and further refinements, the current scheme can be extended to produce designer proteins with diverse forms of authentic posttranslational modifications.
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