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KAIST Annual R&D Report

Dynamic LPS Transfer Mechanism for innate immune response

Writer : GULF Date : 2018-02-14 Hit : 2375 Email : bwo78@kaist.ac.kr
Author : Ho Min Kim Publication Date : 2018-02-14
Summary:
Lipopolysaccharide (LPS), also called endotoxin, is the major component of the outer membrane of Gram-negative bacteria. Transfer of LPS to pattern-recognition receptor complexes, TLR4/MD2, constitutes one of the critical steps in the recognition of a pathogen-associated molecular pattern (PAMP) of Gram-negative bacteria. The accessory proteins, LBP and CD14, mediate this LPS transfer, which eventually leads to induction of innate immune responses for helping clearance of bacterial infections.
Publication text:

 Dynamic LPS Transfer Mechanism for innate immune response 이미지1 

Dynamic LPS Transfer Mechanism for innate immune response 이미지2