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College of Life Science and Bio Engineering

College of Life Science and Bioengineering

With the specialization of biology, brain science, medical science, and IT/NT, KAIST has accumulated academic capability in the area of biology. The College of Life Science and Bioengineering was founded to efficiently support the fusion research environment of KI for Biocentury at KAIST.

The College of Life Science and Bioengineering is composed of the Department of Biological Sciences, Department of Bio & Brain Engineering, and Graduate School of Medical Science & Engineering. The college pursues multidisciplinary education & research in the area of biology and the development of modern science through the fusion of the IT & NT foundation techniques for the development of the nation’s biological science and technology.

The Department of Biological Sciences fosters scientists and engineers of life science and biotechnology equipped with creative research skills to lead in the development of science and technology in the area of biological sciences and excellent scientists equipped with future oriented thinking and a holistic personality.

The multidisciplinary Department of Bio & Brain Engineering fosters a creative workforce that is capable of creating new knowledge and techniques in the fusion areas of electronics, computers, and nanotechnology based on biomedical science.

The Graduate School of Medical Science & Engineering is catered to doctors (specialists), graduates from medical schools, dental schools, and schools of oriental medicine for the development of new medicine and medical devices. The Graduate School of Medical Science & Engineering was established with the purpose of developing life sciences and medical technology and fostering a high-quality workforce equipped with a multidisciplinary knowledge in basic medicine, life science, and biomedical engineering, as well as research experience.

Academic Degree Curriculum
Academic Degree Curriculum
Department/Major Bachelor's Courses Master's Courses Doctoral Courses Office of Academic Affairs Website
Department of Biological Sciences
042-350-2602(F.2610) Homepage go
Graduate School of Medical Science and Engineering
042-350-4232(F.4240) Homepage go
Interdisciplinary Majors and Educational Programs
Education Program
College
(Department/Major)
Interdisciplinary Majors and Educational Programs Bachelor's Courses Master's Courses Doctoral Courses Office of Academic Affairs Website
Graduate School of Medical Science and Engineering
Biomedical Science and Engineering
Interdisciplinary Program
042-350-4232(F.4240) Homepage go
※ Department of Bio and Brain Engineering is changed of affiliation from College of Life Science and Bioengineering to College of Engineering on March 1st, 2015.
KAIST COMPASS in Life Science & Bioengineering
2019 Spring KAIST compass 해당기사, 새창열림 KAIST compass 해당기사, 새창열림 KAIST compass 해당기사, 새창열림 KAIST compass 해당기사, 새창열림 KAIST compass 해당기사, 새창열림 KAIST compass 해당기사, 새창열림 2018 Fall KAIST compass image2 Sexual dimorphism in Chd8 - mutant mice Drug discovery for ciliopathy, a rare genetic disorder Expanding the repertoire of photo-switchable proteins Serine: Link between sleep and metabolism Heterogeneity of exhausted tumor-infiltrating CD8+ T NF2 as a tap handle for tissue growth
News
KAIST Vaccine for Tick-Borne Disease ‘SFTS’ Protects Against Lethal Infection

KAIST Vaccine for Tick-Borne Disease ‘SFTS’ Protects Against Lethal Infection 이미지1

A KAIST research team reported the development of a DNA vaccine for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) which completely protects against lethal infection in ferrets. The team confirmed that ferrets immunized with DNA vaccines encoding all SFTSV proteins showed 100% survival rate without detectable viremia and did not develop any clinical symptoms. This study was published in Nature Communications on August 23.

Severe Fever with Thrombocytopenia Syndrome (SFTS) is a newly emerging tick-borne infectious disease. The disease causes fever, severe thrombocytopenia, leukocytopenia as well as vomiting and diarrhea. Severe cases end up with organ system failure often accompanied by hemorrhages, and its mortality rate stands at 10–20%.

The viral disease has been endemic to East Asia but the spread of the tick vector to North America increases the likelihood of potential outbreak beyond the Far East Asia. The World Health Organization (WHO) has also put SFTSV into the priority pathogen requiring urgent attention category. Currently, no vaccine has been available to prevent SFTS.

The research team led by Professor Su-Hyung Park noted that DNA vaccines induce broader immunity to multiple antigens than traditional ones. Moreover, DNA vaccines stimulate both T cell and antibody immunity, which make them suitable for vaccine development.

They constructed DNA vaccines that encode full-length Gn, Gc, N, NS, and RNA polymerase genes based on common sequences of 31 SFTSV strains isolated from patients. Their vaccine candidates induced both neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice and ferrets.

To investigate the vaccine’s efficacy in vivo, the research team applied a recently developed ferret model that recapitulates fatal clinical symptoms in SFTSV infection in humans. Vaccinated ferrets were completely protected from lethal SFTSV challenge without SFTSV detection in their blood, whereas all control ferrets died within 10 days’ post-infection.

The KAIST team found that anti-envelope antibodies play an important role in protective immunity, suggesting that envelope glycoproteins of SFTSV may be the most effective antigens for inducing protective immunity. Moreover, the study revealed that T cell responses specific to non-envelope proteins of SFTSV also can contribute to protection against SFTSV infection.

Professor Park said, “This is the first study demonstrating complete protection against lethal SFTSV challenge using an immunocompetent, middle-sized animal model with clinical manifestations of SFTSV infection. We believe this study provides valuable insights into designing preventive vaccines for SFTSV.”

Newsletter
Department of Biological Sciences KAIST COMPASS
Contact Information for the College of Life Science and Bioengineering: 042-350-ext.

Office of the Dean of the College of Life Science and Bioengineering: 2125
College of Life Science and Bioengineering Academic and Student Affairs Team: 1401, 1409, Fax: 1400